. 2016 Jun;8(6):1274-82.

doi: 10.21037/jtd.2016.04.66.

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Affiliations

Affiliation

¹ 1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea ; 3 Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 5 Department of Pulmonary, Allergy and Critical Care Medicine, Korea University Guro Hospital, Seoul, Republic of Korea ; 6 Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center, Incheon, Korea ; 7 Department of Internal Medicine, Eulji University College of Medicine, Seoul, Republic of Korea ; 8 Division of Pulmonary, Allergy and Critical Care Medicine Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea ; 9 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea.

PMID: 27293847
PMCID: PMC4885959
DOI: 10.21037/jtd.2016.04.66

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Hwa Young Lee et al. J Thorac Dis. 2016 Jun.

. 2016 Jun;8(6):1274-82.

doi: 10.21037/jtd.2016.04.66.

Authors

Affiliation

¹ 1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea ; 3 Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ; 5 Department of Pulmonary, Allergy and Critical Care Medicine, Korea University Guro Hospital, Seoul, Republic of Korea ; 6 Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center, Incheon, Korea ; 7 Department of Internal Medicine, Eulji University College of Medicine, Seoul, Republic of Korea ; 8 Division of Pulmonary, Allergy and Critical Care Medicine Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea ; 9 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea.

PMID: 27293847
PMCID: PMC4885959
DOI: 10.21037/jtd.2016.04.66

Abstract

Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort.

Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DLCO); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed.

Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms. A total of 51% of patients had high DLCO without CB symptoms [CB (-) high DLCO], 24.9% had CB symptoms only [CB (+) high DLCO], 14.2% had low DLCO only [CB (-) low DLCO], and 10.2% had both low DLCO and CB [CB (+) low DLCO]. Patients with CB (+) low DLCO showed a significantly lower post-bronchodilator (BD) forced expiratory volume for 1 second (FEV1) and more severe dyspnea than patients with CB (-) high DLCO. On multivariate analysis, the risk of acute exacerbation was two times higher [odds ratio (OR) 2.06; 95% confidence interval (CI): 1.18-3.62; P=0.01] in the CB (+) low DLCO group than in the CB (-) high DLCO group.

Conclusions: In this COPD cohort, patients showed distinct clinical characteristics and outcomes according to the presence of CB and degree of DLCO. CB and low DLCO were associated with the risk of acute exacerbation.

Keywords: Chronic bronchitis (CB); acute exacerbation; chronic obstructive lung disease (COPD); diffusing capacity.

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Conflict of interest statement

Conflicts of Interest: CK Rhee has received honoraria for lectures and/or consulting from MSD Korea, AstraZeneca Korea, Novartis Korea, Takeda Korea, GlaxoSmithKline Korea, Mundipharma Korea, Sandoz Korea, and Boehringer-Ingelheim Korea. The other authors have no conflicts of interest to declare.

Figures

**Figure 1**
Distribution of patients according to chronic bronchitis symptom and DL_CO. DL_CO, diffusing capacity of the lung for carbon monoxide.

**Figure 2**
Comparison of clinical parameters between the groups. DL_CO, diffusing capacity of the lung for carbon monoxide.

See this image and copyright information in PMC

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References

1. Halbert RJ, Natoli JL, Gano A, et al. Global burden of COPD: systematic review and meta-analysis. Eur Respir J 2006;28:523-32. 10.1183/09031936.06.00124605 - DOI - PubMed
1. Ferrer M, Alonso J, Morera J, et al. Chronic obstructive pulmonary disease stage and health-related quality of life. The Quality of Life of Chronic Obstructive Pulmonary Disease Study Group. Ann Intern Med 1997;127:1072-9. 10.7326/0003-4819-127-12-199712150-00003 - DOI - PubMed
1. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3:e442. 10.1371/journal.pmed.0030442 - DOI - PMC - PubMed
1. Global initiative for Chronic Obstructive Lung disease. Global strategy for the diagnosis, management and Prevent of chronic obstructive pulmonary disease, updated 2014. Available online: http://www.goldcopd.org/
1. Woodruff PG, Agusti A, Roche N, et al. Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management. Lancet 2015;385:1789-98. 10.1016/S0140-6736(15)60693-6 - DOI - PMC - PubMed

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Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

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Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

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