Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Jun;8(6):E408-11.
doi: 10.21037/jtd.2016.04.44.

Dimethylacetamide-induced occupational toxic hepatitis with a short term recurrence: a rare case report

Wei Gong  1 , Xin Liu  1 , Baoli Zhu  1
Affiliations
Case Reports

Dimethylacetamide-induced occupational toxic hepatitis with a short term recurrence: a rare case report

Wei Gong et al. J Thorac Dis. 2016 Jun.

Abstract

In recent years, N,N-dimethylacetamide (DMAc) is widely used in the textile and plastics industry as a solvent alternative to more toxic N,N-dimethylformamide (DMF). At home and abroad, sporadic group case reports have revealed that DMAc could cause toxic hepatitis and symptoms or signs indicative of liver involvement among workers exposed to DMAc, with severe cases leading to death. This paper reports a rare case of severe acute toxic hepatitis with a short term recurrence induced by occupational contact with DMAc in a polyimide film factory, as well as in-depth analysis via relevant information and literature.

Keywords: Dimethylacetamide (DMAc); acute hepatitis; recurrence.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A time course of biochemistry results for liver enzymes and serum bilirubin. (A) Liver enzymes progression of the patient; (B) serum bilirubin progression of the patient. AST, aspartate aminotransferase; ALT, alanine aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kennedy GL. Toxicology of dimethyl and monomethyl derivatives of acetamide and formamide: a second update. Crit Rev Toxicol 2012;42:793-826. 10.3109/10408444.2012.725028 - DOI - PubMed
    1. Qian YL, Xu CM, Lu YY, et al. Biological limit value for occupational exposure to N, N-dimethylacetamide Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012;30:709-11. - PubMed
    1. Cheng J, Liu Q, Xu B, et al. Effect of N, N-dimethylformamide on oxidation or antioxidation status among occupational exposed workers. Zhonghua Yu Fang Yi Xue Za Zhi 2014;48:28-32. - PubMed
    1. Kennedy GL, Jr, Sherman H. Acute and subchronic toxicity of dimethylformamide and dimethylacetamide following various routes of administration. Drug Chem Toxicol 1986;9:147-70. 10.3109/01480548608998272 - DOI - PubMed
    1. Kim SN. Preclinical toxicology and pharmacology of dimethylacetamide, with clinical notes. Drug Metab Rev 1988;19:345-68. 10.3109/03602538808994140 - DOI - PubMed

Publication types

LinkOut - more resources