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Case Reports
. 2016 May-Jun;7(3):177-9.
doi: 10.4103/2229-5178.182354.

Inverted follicular keratosis successfully treated with imiquimod

Ayse Serap Karadag  1 , Emin Ozlu  1 , Tugba Kevser Uzuncakmak  1 , Necmettin Akdeniz  1 , Bengu Cobanoglu  2 , Berkant Oman  1
Affiliations
Case Reports

Inverted follicular keratosis successfully treated with imiquimod

Ayse Serap Karadag et al. Indian Dermatol Online J. 2016 May-Jun.

Abstract

Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum characterized by exo-endophytic growing. It is thought to be a rare variant of the seborrheic keratosis. The diagnosis of inverted follicular keratosis is generally established histopathologically because clinical differentiation from other lesions is difficult. Herein, we present one such rare case, successfully treated with topical 5% imiquimod cream.

Keywords: Dermatopathology; imiquimod; inverted follicular keratosis.

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Figures

Figure 1
Figure 1
Oval-round, gray-pink, solitary, verrucous, plaque lesion measuring 1.5 × 2.5 cm on the lateral side of the forehead
Figure 2
Figure 2
Endophytic proliferation composed of basaloid and squamous cells (H and E, ×100)
Figure 3
Figure 3
A pseudoinfiltrative pattern with squamous cell area
Figure 4
Figure 4
Post-treatment appearance
See this image and copyright information in PMC

References

    1. Armengot-Carbo M, Abrego A, Gonzalez T, Alarcon I, Alos L, Carrera C, et al. Inverted follicular keratosis: Dermoscopic and reflectance confocal microscopic features. Dermatology. 2013;227:62–6. - PubMed
    1. Mehregan AH. Inverted follicular keratosis is a distinct follicular tumor. Am J Dermatopathol. 1983;5:467–70. - PubMed
    1. Spielvogel RL, Austin C, Ackerman AB. Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. Am J Dermatopathol. 1983;5:427–42. - PubMed
    1. Ruhoy SM, Thomas D, Nuovo GJ. Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: Case report with human papillomavirus studies. J Am Acad Dermatol. 2004;51:411–5. - PubMed
    1. Battistella M, Peltre B, Cribier B. Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: Another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol. 2010;37:1057–63. - PubMed

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