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. 2016 May;4(10):188.
doi: 10.21037/atm.2016.03.03.

High-density lipoprotein cholesterol values independently and inversely predict cardiac troponin T and I concentration

Giuseppe Lippi  1 , Claudia Lo Cascio  1 , Giorgio Brocco  1 , Elisa Danese  1 , Martina Montagnana  1 , Antonella Bassi  1 , Beatrice Caruso  1 , Chiara Bovo  1 , Gian Luca Salvagno  1
Affiliations

High-density lipoprotein cholesterol values independently and inversely predict cardiac troponin T and I concentration

Giuseppe Lippi et al. Ann Transl Med. 2016 May.

Abstract

Background: This retrospective study was planned to establish potential associations between circulating values of cardiac troponins and those of conventional blood lipids.

Methods: The study population consisted of patients attending an inpatient clinic of the University Hospital of Verona during the year 2015 as part of routine cardiovascular risk assessment. No exclusion criteria were applied. Serum lipids including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were measured using reference enzymatic techniques, whereas troponin T (TnT) was measured using a high-sensitivity (HS) immunoassay. A second analysis was also performed in the General Hospital of Verona, extracting data from the local laboratory database of all patients in whom troponin I (TnI) and blood lipids were simultaneously measured during the same year.

Results: In univariate analysis, HS-TnT was found to be associated with age, sex, TC, LDL-C, HDL-C, but not with TG. In multivariate linear regression analysis, age (positive correlation; P<0.001) and HDL-C (negative correlation; P=0.032) remained significantly associated with HS-TnT. The frequency of HS-TnT values >50 ng/L was higher in subjects with HDL-C <1 mmol/L than in those with HDL-C ≥1 mmol/L [odds ratio (OR), 1.84; 95% confidence interval (CI), 1.03-3.32]. The frequency of HS-TnT values >50 ng/L was also higher in elderly subjects than in younger ones (OR, 2.10; 95% CI, 1.15-3.84). The combination of age and HDL-C explained 35% of overall variability of TnT concentration. In the second analysis, HDL-C was also found to be an independent and negative predictor of TnI in multivariate linear regression analysis (P=0.010). The combination of age and HDL-C explained approximately 28% of the overall variability of TnI concentration.

Conclusions: Our study suggests that HDL-C values inversely predict cardiac troponins concentration irrespective of age, sex and other blood lipids.

Keywords: Cardiovascular risk; acute coronary syndrome (ACS); cholesterol; high-density lipoproteins; lipids; troponin.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Inverse correlation between high-density lipoprotein cholesterol (HDL-C) and troponin T (TnT) or troponin I (TnI) concentration in a population of patients admitted to inpatient clinics for routine cardiovascular risk assessment.
Figure 2
Figure 2
Values (median and interquartile range) of troponin T (TnT) in a population of patients admitted to inpatient clinics for routine cardiovascular risk assessment, stratified according to the age and the values of high-density lipoprotein cholesterol (HDL-C). The horizontal line is drawn at the troponin I (TnI) value corresponding to 50 ng/L.
See this image and copyright information in PMC

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