Lymphocyte proliferative responses of patients with ocular toxoplasmosis to parasite and retinal antigens
- PMID: 2729411
- DOI: 10.1016/0002-9394(89)90260-2
Lymphocyte proliferative responses of patients with ocular toxoplasmosis to parasite and retinal antigens
Abstract
In vitro lymphocyte proliferative responses to purified toxoplasma antigens and the retinal S-antigen were evaluated in 40 patients with ocular toxoplasmosis; 16 (40%) had a positive in vitro response to the retinal S-antigen. The proliferative responses to the 2G11 (p22) toxoplasma membrane antigen approached that of a crude antigen preparation of Toxoplasma gondii, whereas the response to the 1E11 immunodominant p30 membrane antigen was considerably less striking. HLA typing was also performed, and none correlated to S-antigen or toxoplasma reactivity. The evidence strongly suggests that patients with a clearly infectious ocular disorder may have part of their disease mediated by a putative autoimmune mechanism. An immune response to the 2G11 toxoplasma antigen may increase the risk of developing ocular disease or a substrain of toxoplasma with 2G11 as its immunodominant membrane antigen may have a greater affinity for the retina.
Similar articles
-
Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis.Exp Parasitol. 2009 Oct;123(2):199-202. doi: 10.1016/j.exppara.2009.06.017. Epub 2009 Jun 28. Exp Parasitol. 2009. PMID: 19567250
-
Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with ocular toxoplasmosis.Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3228-32. Invest Ophthalmol Vis Sci. 2001. PMID: 11726627
-
Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis.Front Immunol. 2021 May 12;12:606963. doi: 10.3389/fimmu.2021.606963. eCollection 2021. Front Immunol. 2021. PMID: 34054794 Free PMC article.
-
[Study and application of surface antigen in tachyzoites of Toxoplasma gondii].Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2014 Dec;26(6):687-9. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2014. PMID: 25856903 Review. Chinese.
-
[Development of immunological antigen for detecting Toxoplasma gondii infection].Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011 Oct;23(5):590-4. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011. PMID: 22263520 Review. Chinese.
Cited by
-
HLA typing in congenital toxoplasmosis.Br J Ophthalmol. 1995 May;79(5):494-7. doi: 10.1136/bjo.79.5.494. Br J Ophthalmol. 1995. PMID: 7612565 Free PMC article.
-
Immunity and Toxoplasma retinochoroiditis.Clin Exp Immunol. 2008 Sep;153(3):309-15. doi: 10.1111/j.1365-2249.2008.03692.x. Epub 2008 Jun 28. Clin Exp Immunol. 2008. PMID: 18549442 Free PMC article. Review.
-
Value of PCR for detection of Toxoplasma gondii in aqueous humor and blood samples from immunocompetent patients with ocular toxoplasmosis.J Clin Microbiol. 1999 Nov;37(11):3465-8. doi: 10.1128/JCM.37.11.3465-3468.1999. J Clin Microbiol. 1999. PMID: 10523535 Free PMC article.
-
Does autoimmunity to S-antigen play a role in Fuchs' heterochromic cyclitis?Br J Ophthalmol. 1993 Jul;77(7):436-9. doi: 10.1136/bjo.77.7.436. Br J Ophthalmol. 1993. PMID: 8343474 Free PMC article.
-
Parasitic diseases of zoonotic importance in humans of northeast India, with special reference to ocular involvement.Eye Brain. 2014 Sep 22;6:1-8. doi: 10.2147/EB.S64404. eCollection 2014. Eye Brain. 2014. PMID: 28539786 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials