Is there a role for continuous infusion of β-lactam antibiotics in severe sepsis?

Affiliations

Comment

Angela Bates et al. J Thorac Dis. 2016 Jun.

. 2016 Jun;8(6):E437-9.

doi: 10.21037/jtd.2016.03.81.

¹ University of Alberta, Stollery Children's Hospital, Edmonton, Alberta, Canada.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis.
Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING II Investigators for the ANZICS Clinical Trials Group *. Dulhunty JM, et al. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1298-305. doi: 10.1164/rccm.201505-0857OC. Am J Respir Crit Care Med. 2015. PMID: 26200166 Clinical Trial.

1. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013;369:840-51. 10.1056/NEJMra1208623 - DOI - PubMed
1. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther 2012;10:701-6. 10.1586/eri.12.50 - DOI - PMC - PubMed
1. Shiu J, Wang E, Tejani AM, et al. Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections. Cochrane Database Syst Rev 2013;3:CD008481. - PMC - PubMed
1. Chant C, Leung A, Friedrich JO. Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis. Crit Care 2013;17:R279. 10.1186/cc13134 - DOI - PMC - PubMed
1. Sinnollareddy MG, Roberts MS, Lipman J, et al. β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review. Clin Exp Pharmacol Physiol 2012;39:489-96. 10.1111/j.1440-1681.2012.05715.x - DOI - PubMed