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Comment
. 2016 Sep;26(9):975-6.
doi: 10.1038/cr.2016.71. Epub 2016 Jun 14.

Dissecting the bone marrow HSC niches

Meng Zhao  1   2 , Linheng Li  1   3
Affiliations
Comment

Dissecting the bone marrow HSC niches

Meng Zhao et al. Cell Res. 2016 Sep.

Abstract

Hematopoietic stem cells (HSCs) sponsoring hematopoiesis are preserved in the bone marrow (BM) microenvironment or niche. Here, Itkin et al. demonstrate how distinct blood vessels contribute to HSC maintenance and hematopoiesis in the BM niches.

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Figures

Figure 1
Figure 1
HSCs in different states are maintained in distinct BM zones. In each zone, blood vessels are constructed by different types of endothelial cells and surrounded by their unique perivascular cells. ROSlow quiescent HSCs are maintained by arteries, endosteal arterioles, and certain sinusoid sites by megakaryocytes. ROShigh active HSCs are kept by sinusoids where leukocyte and HSC trafficking is happening.
See this image and copyright information in PMC

Comment on

  • Distinct bone marrow blood vessels differentially regulate haematopoiesis.
    Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. Itkin T, et al. Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624. Epub 2016 Apr 13. Nature. 2016. PMID: 27074509 Free PMC article.

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