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. 1989 Mar;33(3):391-3.
doi: 10.1128/AAC.33.3.391.

Penetration of pefloxacin into bronchial secretions

G Bonmarchand  1 , J J Grès, G Lerebours, P Massari, J J Mayoux, A Montay, J Leroy
Affiliations

Penetration of pefloxacin into bronchial secretions

G Bonmarchand et al. Antimicrob Agents Chemother. 1989 Mar.

Abstract

Twelve patients, intubated for acute exacerbation of chronic obstructive pulmonary disease, received six intravenous doses of 400 mg of pefloxacin at 12-h intervals. Samples of blood and bronchial secretions were taken simultaneously, before the injection and at 0.5, 3, 6, 9, and 12 h after the end of the sixth infusion. There was a large variation in pefloxacin levels in both serum and bronchial secretions. The mean concentrations of pefloxacin in bronchial secretions ranged from 6.51 to 11.1 micrograms/ml and were higher than the corresponding concentrations in serum at all times. Of 61 bronchial specimens, 48 (79%) contained more than 8 micrograms of the antibiotic per ml.

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