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Comparative Study
. 1989 Apr;33(4):573-5.
doi: 10.1128/AAC.33.4.573.

Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis

R M Tucker  1 , L H Hanson, E Brummer, D A Stevens
Affiliations
Comparative Study

Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis

R M Tucker et al. Antimicrob Agents Chemother. 1989 Apr.

Abstract

ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.

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References

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