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. 1996 Jan;60(7):1191-2.
doi: 10.1271/bbb.60.1191.

Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase from Geotrichum sp. WF9101

M Tatsuma  1 , S Michio  1 , K Takashi  1 , S Takuo  1   2
Affiliations
Free article

Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase from Geotrichum sp. WF9101

M Tatsuma et al. Biosci Biotechnol Biochem. 1996 Jan.
Free article

Abstract

Geotrichum sp. WF9101 could degrade (S)-( + )-l,2-propanediol, (S)-( + )-l,3-butanediol, and (2S,4S)-( # )-2,4-pentanediol, but not the corresponding enantiomers. An NAD(+)-linked secondary alcohol dehydrogenase purified from the strain showed the same enantio-selective oxidations towards these diols. This enzyme is proposed to be useful for the preparation of (R)-( - )-diols from the racemates of these diols.

Keywords: Geotrichum sp.; NAD+-linked secondary alcohol dehydrogenase; enantioselective oxidation of 1,3-butanediol.

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