Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

Rikki A Cannioto¹, Michael J LaMonte², Linda E Kelemen³, Harvey A Risch⁴, Kevin H Eng⁵, Albina N Minlikeeva^{1

2}, Chi-Chen Hong¹, J Brian Szender⁶, Lara Sucheston-Campbell¹, Janine M Joseph¹, Andrew Berchuck⁷, Jenny Chang-Claude^{8

9}, Daniel W Cramer¹⁰, Anna DeFazio¹¹, Brenda Diergaarde¹², Thilo Dörk¹³, Jennifer A Doherty¹⁴, Robert P Edwards^{15

16}, Brooke L Fridley¹⁷, Grace Friel¹⁸, Ellen L Goode¹⁹, Marc T Goodman²⁰, Peter Hillemanns²¹, Estrid Hogdall^{22

23}, Satoyo Hosono²⁴, Joseph L Kelley¹⁵, Susanne K Kjaer^{22

25}, Rüdiger Klapdor²¹, Keitaro Matsuo²⁶, Kunle Odunsi⁶, Christina M Nagle²⁷, Catherine M Olsen²⁷, Lisa E Paddock²⁸, Celeste L Pearce²⁹, Malcolm C Pike³⁰, Mary A Rossing³¹, Barbara Schmalfeldt³², Brahm H Segal³³, Elizabeth A Szamreta³⁴, Pamela J Thompson²⁰, Chiu-Chen Tseng³⁵, Robert Vierkant³⁶, Joellen M Schildkraut³⁷, Nicolas Wentzensen³⁸, Kristine G Wicklund³¹, Stacey J Winham³⁶, Anna H Wu³⁵, Francesmary Modugno^{12

15

16}, Roberta B Ness³⁹, Allan Jensen²², Penelope M Webb²⁷, Kathryn Terry¹⁰, Elisa V Bandera³⁴, Kirsten B Moysich¹

Affiliations

¹ Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
² Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.
³ Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
⁴ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
⁵ Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁶ Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁷ Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
⁸ Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
⁹ Germany and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁰ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Gynecological Oncology, Westmead Hospital and The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
¹² Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
¹³ Gynecology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁴ Department of Epidemiology, The Geisel School of Medicine at Dartmouth Medical, Hanover, NH, USA.
¹⁵ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁶ Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
¹⁷ Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA.
¹⁸ Independent Health, Buffalo, NY, USA.
¹⁹ Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
²⁰ Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
²¹ Hannover Medical School, Clinics of Gynaecology and Obstetrics, Hannover, Germany.
²² Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
²³ Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁴ Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
²⁵ Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
²⁶ Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
²⁷ Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
²⁸ New Jersey State Cancer Registry, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
²⁹ Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
³⁰ Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA.
³¹ Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³² Department of Gynecology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
³³ Departments of Immunology and Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
³⁴ Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
³⁵ Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
³⁶ Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
³⁷ Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
³⁸ Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.
³⁹ The University of Texas School of Public Health, Houston, TX, USA.

PMID: 27299959
PMCID: PMC4931371
DOI: 10.1038/bjc.2016.153

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

Rikki A Cannioto et al. Br J Cancer. 2016.

. 2016 Jun 28;115(1):95-101.

doi: 10.1038/bjc.2016.153. Epub 2016 Jun 14.

Authors

Affiliations

¹ Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
² Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.
³ Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
⁴ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
⁵ Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁶ Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁷ Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
⁸ Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
⁹ Germany and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁰ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Gynecological Oncology, Westmead Hospital and The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
¹² Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
¹³ Gynecology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁴ Department of Epidemiology, The Geisel School of Medicine at Dartmouth Medical, Hanover, NH, USA.
¹⁵ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁶ Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
¹⁷ Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA.
¹⁸ Independent Health, Buffalo, NY, USA.
¹⁹ Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
²⁰ Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
²¹ Hannover Medical School, Clinics of Gynaecology and Obstetrics, Hannover, Germany.
²² Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
²³ Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁴ Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
²⁵ Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
²⁶ Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
²⁷ Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
²⁸ New Jersey State Cancer Registry, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
²⁹ Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
³⁰ Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA.
³¹ Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³² Department of Gynecology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
³³ Departments of Immunology and Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
³⁴ Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
³⁵ Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
³⁶ Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
³⁷ Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
³⁸ Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.
³⁹ The University of Texas School of Public Health, Houston, TX, USA.

PMID: 27299959
PMCID: PMC4931371
DOI: 10.1038/bjc.2016.153

Abstract

Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.

Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years.

Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively.

Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

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References

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Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

Affiliations

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

Authors

Affiliations

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical