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. 2016 Jun 24;79(6):1524-31.
doi: 10.1021/acs.jnatprod.5b01037. Epub 2016 Jun 14.

7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

Emmanoel V Costa  1 , Maria Lúcia B Pinheiro  1 , Beatriz Helena L N S Maia  2 , Francisco A Marques  2 , Ana Lúcia T G Ruiz  3 , Gabriela M Marchetti  3 , João Ernesto de Carvalho  3 , Milena B P Soares  4   5 , Cinara O S Costa  4 , Alexandre F C Galvão  4 , Norberto P Lopes  6 , Hector H F Koolen  7 , Daniel P Bezerra  4 , Andersson Barison  2
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7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

Emmanoel V Costa et al. J Nat Prod. .

Abstract

Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.

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