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Comment
. 2016 Jun 13;29(6):774-776.
doi: 10.1016/j.ccell.2016.05.013.

Pancreatic Cancer: Planning Ahead for Metastatic Spread

Ingunn M Stromnes  1 , Philip D Greenberg  2
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Pancreatic Cancer: Planning Ahead for Metastatic Spread

Ingunn M Stromnes et al. Cancer Cell. .
Free article

Abstract

Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperatively but not individually prolongs survival.

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