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Comment
. 2016 Sep;29(5):490-1.
doi: 10.1111/pcmr.12499. Epub 2016 Aug 3.

Stressing out melanoma with an anti-GRP78 compound

Yiwen Bu, J Alan Diehl  1
Affiliations
Comment

Stressing out melanoma with an anti-GRP78 compound

Yiwen Bu et al. Pigment Cell Melanoma Res. 2016 Sep.
No abstract available

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Figures

Figure 1
Figure 1. Mechanisms of HA15 targeting melanoma cells. HA15 potently binds and inhibits GRP78 activity in the ER
All three ER stress transducers PERK, IRE-1 and ATF6, when released from GRP78 binding undergo a conformational change. Their activation directly or indirectly triggers Chop accumulation, which represents a point of convergence for all three UPR signaling branches. As a key transcription factor, Chop mediates expression of multiple autophagic and apoptotic gene, eventually resulting in melanoma cell death. The brown squiggles represent misfolded proteins.
See this image and copyright information in PMC

Comment on

  • Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
    Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H, Passeron T, Hofman V, Mograbi B, Dabert-Gay AS, Debayle D, Alcor D, Rabhi N, Annicotte JS, Héliot L, Gonzalez-Pisfil M, Robert C, Moréra S, Vigouroux A, Gual P, Ali MMU, Bertolotto C, Hofman P, Ballotti R, Benhida R, Rocchi S. Cerezo M, et al. Cancer Cell. 2016 Jun 13;29(6):805-819. doi: 10.1016/j.ccell.2016.04.013. Epub 2016 May 26. Cancer Cell. 2016. PMID: 27238082

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