Reply to Mäkinen and Ala-Korpela: Small-scale but accurate metabolomics with high reproducibility for identifying age-related blood metabolites

Affiliations

¹ Geriatric Unit, Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan;
² G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0495, Japan myanagid@gmail.com.

Comment

Hiroshi Kondoh et al. Proc Natl Acad Sci U S A. 2016.

. 2016 Jun 21;113(25):E3471-2.

doi: 10.1073/pnas.1607149113. Epub 2016 Jun 14.

¹ Geriatric Unit, Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan;
² G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0495, Japan myanagid@gmail.com.

No abstract available

Conflict of interest statement

The authors declare no conflict of interest.

Metabolomics of aging requires large-scale longitudinal studies with replication.
Mäkinen VP, Ala-Korpela M. Mäkinen VP, et al. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3470. doi: 10.1073/pnas.1607062113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303027 Free PMC article. No abstract available.

1. Mäkinen V-P, Ala-Korpela M. Metabolomics of aging requires large-scale longitudinal studies with replication. Proc Natl Acad Sci USA. 2016;113:E3470. - PMC - PubMed
1. Sreekumar A, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457(7231):910–914. - PMC - PubMed
1. Chaleckis R, Murakami I, Takada J, Kondoh H, Yanagida M. Individual variability in human blood metabolites identifies age-related differences. Proc Natl Acad Sci USA. 2016;113(16):4252–4259. - PMC - PubMed
1. Chaleckis R, et al. Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites. Mol Biosyst. 2014;10(10):2538–2551. - PubMed
1. Ouchi M, et al. Effects of sex and age on serum 1,5-anhydroglucitol in nondiabetic subjects. Exp Clin Endocrinol Diabetes. 2012;120(5):288–295. - PubMed