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. 2016 Apr;7(2):137-42.
doi: 10.15412/J.BCN.03070207.

Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

Mohammad Hasan Davami  1 , Rasoul Baharlou  1 , Abbas Ahmadi Vasmehjani  1 , Ahmad Ghanizadeh  2 , Mitra Keshtkar  3 , Iman Dezhkam  4 , Mohammad Reza Atashzar  1
Affiliations

Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

Mohammad Hasan Davami et al. Basic Clin Neurosci. 2016 Apr.

Abstract

Introduction: Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls.

Methods: Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA.

Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/mL (P>0.05).

Conclusion: Considering pro-inflammatory cytokines, current results support the association of inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.

Keywords: Inflammatory response; Interleukin-17; Major depressive disorder; Transforming growth factor-beta; interleukin-21.

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Figures

Figure 1.
Figure 1.
Serum concentrations of IL-17, TGF-β and IL-21 in the peripheral blood of MDD patients and blood of normal controls. Presented data were analyzed with the nonparametric two-tailed Mann-Whitney test and the horizontal lines are showing the median of the groups. Significant difference was found in the serum concentrations of IL-17 (A) and TGF-β (B) among patients compared to healthy controls. No Significant difference was found in the serum concentrations of IL-21 (C) among patients compared to healthy controls.
See this image and copyright information in PMC

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