Iatrogenic Seeding of Tumor Cells in Thigh Soft Tissue Upon Surgical Removal of Intracranial Meningioma

Abstract

Introduction: Meningioma is a benign and slowly-growing tumor that is responsible for 20% of brain neoplasms. It can be accompanied by some genetic disorders such as neurofibromatosis type 2 and is more common among women. As a space occupying lesion, it produces a wide range of signs and symptoms by compressing the adjacent and underlying tissues in the brain. Trauma and viruses are possible etiologies for meningioma. The ideal treatment of benign meningioma is surgical resection.

Case presentation: In this case report, we present a middle-aged man with a seeding metastasis of the cranial meningioma (after its removal) in the left thigh. During the removal operation, fascia lata had been used to repair the dura mater and the skin defect was repaired primarily.

Conclusion: We believe that the occurrence of meningioma at the site of incision in the thigh is related to using the same surgical instruments for the removal of the brain tumor.

Keywords: Implantation; Meningioma; Seeding.

Figure 1.

CT scanning image showing a space occupying lesion in the parietal zone of the left hemisphere (April 2001).

Figure 2.

Reconstruction by performing a split thickness graft from the other tigh (July 2007).

Figure 3.

This figure shows post resection defect of the left tigh (July 2007).

Figure 4a._Figure 4b.

Microscopic views show fibrofatty and muscle tissue with nests of meningioma by round to oval benign nuclei and syncytial acidophil cytoplasm with whorle pattern (H & E staining 400 #) (August 2007).