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Review
. 2016 Jul 19;7(29):45757-45763.
doi: 10.18632/oncotarget.9937.

Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma

Dong Dong  1   2 , Yang Zou  1 , Pan Zhang  1 , Zhihong Wu  2   3
Affiliations
Review

Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma

Dong Dong et al. Oncotarget. .

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancy in the world. In order to comprehensively examine the association between genetic variants and risk of HCC, a systematic literature search and meta-analyses of the evidences have been performed. With the data from 301 articles, we conducted meta-analyses for 69 polymorphisms involving 46 distinct genes. The result showed that 31 polymorphisms in 25 genes are significantly associated with HCC risk. Cumulative epidemiological evidence for a significant association with HCC risk was graded strong for one polymorphism (NQO1 rs1800566). Furthermore, we provided a database to integrate and analyze the association of genetic variants and HCC risk. To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis of genetic association with HCC risk. We have provided a useful resource and platform for investigators to explore the association of sequence polymorphisms and HCC risk.

Keywords: hepatocellular carcinoma; meta-analyses.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Profiles of literature search, meta-analysis and evaluation of cumulative evidence
See this image and copyright information in PMC

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