Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 14;23(6):965-966.
doi: 10.1016/j.cmet.2016.05.022.

Why NAD(+) Declines during Aging: It's Destroyed

Michael B Schultz  1 , David A Sinclair  2
Affiliations

Why NAD(+) Declines during Aging: It's Destroyed

Michael B Schultz et al. Cell Metab. .

Abstract

NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.

PubMed Disclaimer

Conflict of interest statement

D.A.S. is a consultant and/or inventor on patents licensed to GlaxoSmithKline, Ovascience, Metrobiotech, Caudalie, and Liberty Biosecurity.

Figures

Figure 1
Figure 1. CD38 Regulates Metabolism during Aging through Modulating NAD+ Levels and SIRT3 Activity
CD38 is a membrane-bound NADase that hydrolyzes NAD+ to nicotinamide and (cyclic-)ADP-ribose. Its protein levels increase during aging, with a corresponding increase in NADase activity and declining NAD+ levels. Mice deficient for CD38 are protected from mitochondrial dysfuntion and diabetes during aging. Many of these effects are mediated through the mitochondrial sirtuin SIRT3. As CD38 also degrades NMN, the CD38 knockout mice also are more sensitive to treatment with NAD+ precursors.
See this image and copyright information in PMC

Comment on

  • Cell Metab.

References

    1. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. J Biol Chem. 2002;277:18881–18890. - PubMed
    1. Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, et al. Cell Metab. 2011;13:461–468. - PMC - PubMed
    1. Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EM. Cell Metab. 2016;23:1127–1139. this issue. - PMC - PubMed
    1. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O’Neil L, White TA, Sinclair DA, Chini EN. Diabetes. 2013;62:1084–1093. - PMC - PubMed
    1. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JSS, Wrann CD, Hubbard BP, et al. Cell. 2013;155:1624–1638. - PMC - PubMed