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Review
. 2016 Jun 14;23(6):1004-1012.
doi: 10.1016/j.cmet.2016.05.013.

A Ribosomal Perspective on Proteostasis and Aging

Kristan K Steffen  1 , Andrew Dillin  2
Affiliations
Free article
Review

A Ribosomal Perspective on Proteostasis and Aging

Kristan K Steffen et al. Cell Metab. .
Free article

Abstract

As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.

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