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Review
. 2014 Jul 15;1(1):e29899.
doi: 10.4161/mco.29899. eCollection 2014.

Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis

Tomohisa Baba  1 , Naofumi Mukaida  1
Affiliations
Review

Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis

Tomohisa Baba et al. Mol Cell Oncol. .

Abstract

The biologic function of the CC chemokine macrophage inflammatory protein-1α (MIP-1α/CCL3) has been extensively studied since its initial identification as a macrophage-derived inflammatory mediator. In addition to its proinflammatory activities, CCL3 negatively regulates the proliferation of hematopoietic stem/progenitor cells (HSPCs). On the basis of this unique function, CCL3 is alternatively referred to as a stem cell inhibitor. This property has prompted many researchers to investigate the effects of CCL3 on normal physiologic hematopoiesis and pathophysiologic processes of hematopoietic malignancies. Consequently, there is accumulating evidence supporting a crucial involvement of CCL3 in the pathophysiology of several types of leukemia arising from neoplastic transformation of HSPCs. In this review we discuss the roles of CCL3 in leukemogenesis and its potential value as a target in a novel therapeutic strategy for the treatment of leukemia.

Keywords: MIP-1α/CCL3; chemokine; leukemia; leukemia initiating cell; microenvironment.

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Figures

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Figure 1. Function of CCL3 in the leukemic bone marrow microenvironment. In the leukemic BM microenvironment (blue shaded area), CCL3 can induce multiple processes that support the dominant proliferation of leukemia cells: (1) conversion of normal niche cells to leukemia-adapted cells; (2) selective inhibition of normal HSPCs; (3) mobilization of normal HSPCs from BM. Abbreviations: BM, bone marrow; HSPC, hematopoietic stem/progenitor cell
See this image and copyright information in PMC

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