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. 2014 Dec 23;1(3):e970055.
doi: 10.4161/23723548.2014.970055. eCollection 2014 Jul-Sep.

Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers

Francesca Cottini  1 , Kenneth C Anderson  2 , Giovanni Tonon  3
Affiliations

Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers

Francesca Cottini et al. Mol Cell Oncol. .

Abstract

Unrestrained oncogene activity triggers DNA damage. Cancer cells exploit various stratagems to deal with this potentially lethal event. We found that hematologic cancer cells inactivate the Hippo co-activator Yes-associated protein 1 (YAP1). A synthetic lethal approach is proposed whereby inhibition of the serine/threonine kinase 4 (STK4) could be exploited to restore YAP1 levels in hematologic cancers.

Keywords: STK4; YAP-1; multiple myeloma; tumor suppressor.

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Figures

Figure 1.
Figure 1.
Yes-associated protein 1 (YAP1)-mediated apoptosis in hematologic cancers. Left panel: ongoing DNA damage induces shuttling of ABL1 into the nucleus. Serine/threonine kinase 4 (STK4)-mediated suppression of YAP1 prevents the occurrence of apoptosis. Right panel: STK4 downregulation relieves the inhibition on YAP1, which in turn interacts with ABL1 and p73, inducing apoptosis.
See this image and copyright information in PMC

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