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. 2015 Feb 23;3(1):e1014757.
doi: 10.1080/23723556.2015.1014757. eCollection 2016 Jan.

Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F Boj  1 , Chang-Il Hwang  2 , Lindsey A Baker  2 , Dannielle D Engle  2 , David A Tuveson  3 , Hans Clevers  4
Affiliations

Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F Boj et al. Mol Cell Oncol. .

Abstract

We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Keywords: cancer; organoids; pancreatic ductal adenocarcinoma; preclinical models.

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Figures

Figure 1.
Figure 1.
Organoids from healthy and neoplastic pancreas. Resected pancreatic tissues (top) and derived organoids (bottom). Hematoxylin and eosin staining; scale bars = 100 microns.
See this image and copyright information in PMC

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