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. 2015 Aug 28;3(2):e1084443.
doi: 10.1080/23723556.2015.1084443. eCollection 2016 Mar.

Circular RNA expands its territory

Chunyang Bao  1 , Dongbin Lyu  1 , Shenglin Huang  1
Affiliations

Circular RNA expands its territory

Chunyang Bao et al. Mol Cell Oncol. .

Abstract

Circular RNAs (circRNAs) represent a novel class of widespread non-coding RNAs in eukaryotes. They are unusually stable RNA molecules with cell type-specific expression patterns, and are predominantly present in the cytoplasm. We recently demonstrated the existence of abundant circRNAs in exosomes and suggest a potential application of exosomal circRNAs for cancer detection.

Keywords: Cancer biomaker; circular RNA; exosomes; microRNA; non-coding RNA.

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Figures

Figure 1.
Figure 1.
Possible mechanisms underlying the biogenesis, activity, and metabolism of circular RNA. Circular RNA (circRNA) acquires its ring formation from back-spliced exons through intron-pairing or RBP (RNA binding protein)-associated pairing in the nucleus. After transfer into the cytoplasm, circRNA can either bind with miRNAs to exert certain biological functions, or be sorted into multivesicular endosomes (MVEs) together with a wealthy cargo of other nucleic acids and proteins. The exosomes are secreted from the cells into body fluid, through which circRNAs are circulated and may serve as potential biomarkers.
See this image and copyright information in PMC

References

    1. Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol 2014; 32:453–461; PMID:24811520; http://dx.doi.org/ 10.1038/nbt.2890 - DOI - PMC - PubMed
    1. Glazar P, Papavasileiou P, Rajewsky N. CircBase: a database for circular RNAs. RNA 2014; 20:1666–70; PMID:25234927; http://dx.doi.org/ 10.1261/rna.043687.113 - DOI - PMC - PubMed
    1. Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol 2015; 12:381–8; PMID:25746834; http://dx.doi.org/ 10.1080/15476286.2015.1020271 - DOI - PMC - PubMed
    1. Rybak-Wolf A, Stottmeister C, Glazar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, et al. Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol Cell 2015; 58:870–85; PMID:25921068; http://dx.doi.org/ 10.1016/j.molcel.2015.03.027 - DOI - PubMed
    1. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. The RNA binding protein quaking regulates formation of circRNAs. Cell 2015; 160:1125–34; PMID:25768908; http://dx.doi.org/ 10.1016/j.cell.2015.02.014 - DOI - PubMed

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