Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment
- PMID: 27312404
- PMCID: PMC5061894
- DOI: 10.1038/npp.2016.94
Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment
Comment on
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The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects.Neuropsychopharmacology. 2016 Nov;41(12):2818-2829. doi: 10.1038/npp.2016.61. Epub 2016 Apr 25. Neuropsychopharmacology. 2016. PMID: 27109623 Free PMC article. Clinical Trial.
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- Cole BJ, Cador M, Stinus L, Rivier J, Vale W, Koob GF (1990). Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization. Brain Res 512: 343–346. - PubMed
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- Fleck BA, Hoare SR, Pick RR, Bradbury MJ, Grigoriadis DE (2012). Binding kinetics redefine the antagonist pharmacology of the corticotropin-releasing factor type 1 receptor. J Pharmacol Exp Ther 341: 518–531. - PubMed
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