Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network

Charlotte Osafo¹, Yemi R Raji², Timothy Olanrewaju³, Manmak Mamven⁴, Fatiu Arogundade⁵, Samuel Ajayi⁴, Ifeoma Ulasi⁶, Babatunde Salako², Jacob Plange-Rhule⁷, Yewondwossen Mengistu⁸, S O Mc'Ligeyo⁹, George Moturi⁹, Cheryl A Winkler¹⁰, Marva M Moxey-Mims¹¹, Rebekah S Rasooly¹¹, Paul Kimmel¹¹, Dwomoa Adu¹², Akinlolu Ojo¹³, Rulan S Parekh¹⁴; H3Africa Kidney Disease Research Network

Affiliations

¹ School of Medicine and Dentistry, University of Ghana, Accra, Ghana. Electronic address: ceyosafo@gmail.com.
² Department of Medicine, University of Ibadan, Ibadan, Nigeria.
³ Department of Medicine, University of Ilorin, Ilorin, Nigeria.
⁴ Department of Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria.
⁵ Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria.
⁶ Department of Medicine, University of Nigeria, Enugu, Nigeria.
⁷ Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
⁸ Department of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
⁹ Department of Medicine, University of Nairobi, Nairobi, Kenya.
¹⁰ Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
¹¹ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹² School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
¹³ Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
¹⁴ Departments of Pediatrics and Medicine, Hospital for Sick Children, University of Health Network, University of Toronto, Toronto, Ontario, Canada.

PMID: 27312436
PMCID: PMC4991770
DOI: 10.1016/j.kint.2015.12.059

Case Reports

Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network

Charlotte Osafo et al. Kidney Int. 2016 Jul.

. 2016 Jul;90(1):2-5.

doi: 10.1016/j.kint.2015.12.059.

Authors

Affiliations

¹ School of Medicine and Dentistry, University of Ghana, Accra, Ghana. Electronic address: ceyosafo@gmail.com.
² Department of Medicine, University of Ibadan, Ibadan, Nigeria.
³ Department of Medicine, University of Ilorin, Ilorin, Nigeria.
⁴ Department of Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria.
⁵ Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria.
⁶ Department of Medicine, University of Nigeria, Enugu, Nigeria.
⁷ Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
⁸ Department of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
⁹ Department of Medicine, University of Nairobi, Nairobi, Kenya.
¹⁰ Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
¹¹ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹² School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
¹³ Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
¹⁴ Departments of Pediatrics and Medicine, Hospital for Sick Children, University of Health Network, University of Toronto, Toronto, Ontario, Canada.

PMID: 27312436
PMCID: PMC4991770
DOI: 10.1016/j.kint.2015.12.059

No abstract available

Keywords: APOL 1; Africa; chronic kidney disease; genomics.

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Figures

**Figure 1**
Map of Africa showing the distribution of APOL1 risk alleles and of Trypanosoma brucei subspecies.

See this image and copyright information in PMC

Comment in

Counterfeit and substandard drugs in Sub-Saharan Africa may pose a major hurdle to H3Africa's initiative to study genetics of kidney disease progression.
Banerjee Y. Banerjee Y. Kidney Int. 2017 Jan;91(1):252-253. doi: 10.1016/j.kint.2016.08.034. Kidney Int. 2017. PMID: 28003084 No abstract available.
The Authors Reply.
Osafo C, Adu D, Moxey Mims M, Parekh R. Osafo C, et al. Kidney Int. 2017 Jan;91(1):253. doi: 10.1016/j.kint.2016.09.025. Kidney Int. 2017. PMID: 28003085 No abstract available.

References

1. Alleyne G, Binagwaho A, Haines A, Jahan S, Nugent R, Rojhani A, et al. Embedding non-communicable diseases in the post-2015 development agenda. Lancet. 2013;381(9866):566–574. - PubMed
1. Stanifer JW, Jing B, Tolan S, Helmke N, Mukerjee R, Naicker S, et al. The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(3):e174–e181. - PubMed
1. Naicker S. Burden of end-stage renal disease in sub-Saharan Africa. Clin Nephrol. 2010;74(Suppl 1):S13–S16. - PubMed
1. Arogundade FA, Barsoum RS. CKD prevention in Sub-Saharan Africa: a call for governmental, nongovernmental, and community support. Am J Kidney Dis. 2008;51(3):515–523. - PubMed
1. Ulasi II, Ijoma CK. The enormity of chronic kidney disease in Nigeria: the situation in a teaching hospital in South-East Nigeria. Journal of tropical medicine. 2010;2010:501957. - PMC - PubMed

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Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network

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Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network

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