Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?
- PMID: 27312438
- DOI: 10.1016/j.kint.2016.05.008
Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?
Abstract
In rodent models, female sex has been shown to be protective against ischemia-reperfusion injury. A recent publication suggests that this sex-dependent response to injury may have clinical implications for delayed graft function after kidney transplantation.
Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
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Improved renal ischemia tolerance in females influences kidney transplantation outcomes.J Clin Invest. 2016 May 2;126(5):1968-77. doi: 10.1172/JCI84712. Epub 2016 Apr 18. J Clin Invest. 2016. PMID: 27088798 Free PMC article.
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