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. 2016 May 27:9:3181-5.
doi: 10.2147/OTT.S95128. eCollection 2016.

Clinical features and treatment of squamous cell carcinoma of the breast

Ximei Zhang  1 , Baozhong Zhang  1 , Fenglin Zang  2 , Lujun Zhao  1 , Zhiyong Yuan  1 , Ping Wang  1
Affiliations

Clinical features and treatment of squamous cell carcinoma of the breast

Ximei Zhang et al. Onco Targets Ther. .

Abstract

Objectives: Data on breast squamous cell carcinoma (SCC) are rare. The aim of this study was to analyze the clinical characteristics and to explore the rational treatment of patients with breast SCC.

Patients and methods: We conducted a retrospective review of breast SCC cases treated at our center from 1966 to 2014. The majority of these patients received primary surgery followed by adjuvant chemoradiotherapy, whilst four elderly patients had lumpectomy only.

Results: Patients with breast SCC were usually women, and large masses, large proportion of early stage disease, low levels of estrogen receptor expression, less frequent axillary lymph nodes involvement, and unfavorable prognosis were common. The 5-year overall survival and progression-free survival of all patients were 67.2% and 57.8%, respectively. Axillary nodal involvement was a significant prognostic factor for survival.

Conclusion: The current results indicated that breast SCC is clinically aggressive and the outcomes were poor. Distant metastasis was the main failure pattern. New strategies will be needed because of the poor outcomes.

Keywords: breast SCC; breast metaplastic carcinoma; prognosis; surgery; treatment.

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Figures

Figure 1
Figure 1
OS and PFS rates in 30 patients with breast squamous cell carcinoma. Abbreviations: OS, overall survival; PFS, progression-free survival.
Figure 2
Figure 2
(A) OS and (B) PFS rates in 30 patients who had or did not have positive axillary lymph nodes. Abbreviations: LN, lymph node; OS, overall survival; PFS, progression-free survival.
See this image and copyright information in PMC

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