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. 2016 Jul;22(7):1283-5.
doi: 10.3201/eid2207.160048.

Highly Pathogenic Avian Influenza Viruses and Generation of Novel Reassortants, United States, 2014-2015

Dong-Hun Lee, Justin Bahl, Mia Kim Torchetti, Mary Lea Killian, Hon S Ip, Thomas J DeLiberto, David E Swayne

Highly Pathogenic Avian Influenza Viruses and Generation of Novel Reassortants, United States, 2014-2015

Dong-Hun Lee et al. Emerg Infect Dis. 2016 Jul.

Abstract

Asian highly pathogenic avian influenza A(H5N8) viruses spread into North America in 2014 during autumn bird migration. Complete genome sequencing and phylogenetic analysis of 32 H5 viruses identified novel H5N1, H5N2, and H5N8 viruses that emerged in late 2014 through reassortment with North American low-pathogenicity avian influenza viruses.

Keywords: HPAI; North America; United States; bird; clade 2.3.4.4; highly pathogenic avian influenza virus; influenza; migration; phylogenetic analysis; reassortant; reassortment; viruses; waterfowl.

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Figures

Figure
Figure
Schematic diagram of the H5 clade 2.3.4.4 highly pathogenic avian influenza virus genotypes identified in this study, United States, 2014–2015. Reassortant H5N8 comprises Eurasian PB2, PA, HA, NP, M, and NS gene segments, and North American PB1 and PA gene segments; reassortant H5N2 comprises Eurasian PB2, PA, HA, M, and NS gene segments, and North American NA, PB1, and NP gene segments; reassortant H5N1 comprises Eurasian HA, NP, M, and PB2 gene segments and North American NA, NS, PA, and PB1 gene segments. HA, hemagglutinin; LPAI, low-pathogenicity avian influenza; M, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB1, polymerase basic 1; PB2, polymerase basic 2.
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