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. 2016 Dec;22(12):2157-2159.
doi: 10.3201/eid2212.160131. Epub 2016 Dec 15.

Hepatitis E Virus in 3 Types of Laboratory Animals, China, 2012-2015

Lin Wang, Yulin Zhang, Wanyun Gong, William Tianshi Song, Ling Wang

Hepatitis E Virus in 3 Types of Laboratory Animals, China, 2012-2015

Lin Wang et al. Emerg Infect Dis. 2016 Dec.

Abstract

We found seroprevalences for hepatitis E virus (HEV) of 7.5%, 18.5%, and 83.3% in specific pathogen-free (SPF) laboratory rabbits, monkeys, and pigs, respectively, in China. HEV RNA was detected in 4.8% of SPF rabbits, and 11 rabbits had latent infections. Screening for HEV in SPF animals before relevant experiments are conducted is recommended.

Keywords: China; HEV; hepatitis E virus; laboratory animals; monkeys; pigs; rabbits; virus latency; viruses.

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Figures

Figure
Figure
Phylogenetic analysis of hepatitis E virus (HEV) isolates from specific pathogen-free (SPF) rabbits, China, 2012−2015. The phylogenetic tree was constructed by using the neighbor-joining method, a partial nucleotide sequence of the open reading frame 2 region, and reported HEV sequences in GenBank as references. One thousand resamplings of the data were used to calculate percentages (values along branches) of tree branches obtained. Black circles indicate SPF rabbit isolates obtained during this study. GenBank accession numbers of all reference sequences (in parentheses) are FJ906895 (GDC9), AB740222 (rbIM004), JX565469 (CMC-1), AB740221 (rbIM022), GU937805 (ch-bj-n1), JX121233 (CHN-BJ-R14), JQ013793 (TLS-18516), JQ013792 (W7-57), AF455784 (Osh-205), AF060668 (US1), AY115488 (swArkell), AB189070 (JBOAR-1Hyo04), AP003430 (JRA1), JF309217 (GS-NJ-10), AY723745 (IND-SW-00-01), AB097812 (HE-JA1), M74506 (Mexican), AY204877 (T3-Chad), and AF459438 (Yam67). Scale bar indicates nucleotide substitutions per site.
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