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. 2016 Jun 16;165(7):1560.
doi: 10.1016/j.cell.2016.05.080.

A BH3 Mimetic for Killing Cancer Cells

Douglas R Green  1
Affiliations
Free article

A BH3 Mimetic for Killing Cancer Cells

Douglas R Green. Cell. .
Free article

Abstract

Venetoclax is a BH3 mimetic approved for treating chronic lymphocytic leukemia. Cancer cells are resistant to apoptosis but "primed for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check. Venetoclax releases this antagonism and is the first approved drug to target a protein-protein interaction.

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