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. 2016 Jun 16;165(7):1820-1820.e1.
doi: 10.1016/j.cell.2016.06.002.

SnapShot: Mechanosensing Matrix

Jerome Irianto  1 , Charlotte R Pfeifer  1 , Yuntao Xia  1 , Dennis E Discher  1
Affiliations

SnapShot: Mechanosensing Matrix

Jerome Irianto et al. Cell. .

Abstract

Cells sense and respond to properties of their microenvironment that can affect cell morphology, protein levels and localization, gene expression, and even nuclear integrity. Tissue micro-stiffness, largely influenced by extracellular matrix, varies dramatically within an organism and can be a useful parameter to both clarify and organize a wide range of cell and molecular processes, such as genomic changes in cancer.

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