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Comment
. 2016 Jun 16;62(6):805-807.
doi: 10.1016/j.molcel.2016.05.035.

Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2

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Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2

Abhinav K Jain et al. Mol Cell. .
Free article

Abstract

Evidence mounts, via two studies published in Molecular Cell (Riscal et al., 2016; Wienken et al., 2016), that chromatin-bound MDM2 impacts pluripotency and metabolism to promote survival and proliferation of cancer cells, independently of p53 degradation.

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