Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2
- PMID: 27315554
- DOI: 10.1016/j.molcel.2016.05.035
Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2
Abstract
Evidence mounts, via two studies published in Molecular Cell (Riscal et al., 2016; Wienken et al., 2016), that chromatin-bound MDM2 impacts pluripotency and metabolism to promote survival and proliferation of cancer cells, independently of p53 degradation.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.Mol Cell. 2016 Jan 7;61(1):68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31. Mol Cell. 2016. PMID: 26748827 Free PMC article.
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Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.Mol Cell. 2016 Jun 16;62(6):890-902. doi: 10.1016/j.molcel.2016.04.033. Epub 2016 Jun 2. Mol Cell. 2016. PMID: 27264869
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