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Review
. 2017 Jan;8(1):8-15.
doi: 10.1016/j.jgo.2016.06.003. Epub 2016 Jun 16.

How should older adults with cancer be evaluated for frailty?

Megan Huisingh-Scheetz  1 , Jeremy Walston  2
Affiliations
Review

How should older adults with cancer be evaluated for frailty?

Megan Huisingh-Scheetz et al. J Geriatr Oncol. 2017 Jan.

Abstract

Traditionally used as a descriptive term, frailty is now a recognized medical syndrome identifying individuals with decreased physiologic reserve. Frailty is characterized by diminished strength, endurance, and reduced physiologic function. Several valid frailty screening tools exist in the literature, and these measures have been used to relate frailty to outcomes important to the older patient with cancer. Frail adults are at increased risk of adverse surgical outcomes and early findings suggest that frailty predicts poor chemotherapy tolerance. While much research is needed to explore the biologic relationships between frailty and cancer, there is an urgent need to implement frailty screening and management into the care of the older patient with cancer in order to improve outcomes in this vulnerable subset. The purpose of this paper is to provide an introduction of frailty to oncologists including a review of the definition, frailty screening tools, its clinical relevance to older patients with cancer, and a brief guide to frailty management.

Keywords: Cancer; Frailty; Older adults.

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Conflict of interest statement

and Conflict of Interest Statements The authors have no conflicts of interest to report

References

    1. Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14:392–397. - PMC - PubMed
    1. Walston JD, Bandeen-Roche K. Frailty: a tale of two concepts. BMC Med. 2015;13:185. - PMC - PubMed
    1. Robinson TN, Walston JD, Brummel NE, et al. Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015 - PMC - PubMed
    1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–156. - PubMed
    1. Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991–1001. - PubMed

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