Intravenous and Oral Contrast vs Intravenous Contrast Alone Computed Tomography for the Visualization of Appendix and Diagnosis of Appendicitis in Adult Emergency Department Patients

Abstract

Purpose: The study sought to compare radiologist's ability to 1) visualize the appendix; 2) diagnose acute appendicitis; and 3) diagnose alternative pathologies responsible for acute abdominal pain among adult patients undergoing computed tomography (CT) scan with 3 different protocols: 1) intravenous (IV) contrast only; 2) IV and oral contrast with 1-hour transit time; and 3) IV and oral contrast with 3-hour transit time.

Methods: We collected data of 225 patients; 75 consecutive patients with a clinical suspicion of appendicitis received oral contrast for 3 hours and IV contrast, 75 received oral contrast for 1 hour and IV contrast, and 75 trauma patients received IV contrast only. Three independent reviewers, blinded to final pathology, retrospectively analysed the cases and documented visualization of the appendix, periappendiceal structures, and their confidence in diagnosing appendicitis. Clinical diagnoses were derived from a combination of clinical, surgical, pathologic, or radiologic follow-up.

Results: Frequency of visualizing the appendix within IV group alone was 87.3%, IV with oral for 1 hour was 94.1%, and IV with oral for 3 hours was 93.8%. Both oral contrast groups had 100% sensitivity and negative predictive value in diagnosis of acute appendicitis. Specificity for the 1- and 3-hour oral contrast groups was 94.1% and 96.1%, respectively and positive predictive value for both groups was 92%.

Conclusions: Our findings suggest that reader confidence in visualizing the appendix improved with addition of oral contrast as compared to IV contrast alone. One- and 3-hour oral regimens have a similar diagnostic performance in diagnosing appendicitis.

Keywords: Appendicitis; Appendix; Computed tomography; Oral contrast.