Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity

Abstract

Since microtubules have an important role in mitosis and other vital cellular functions, tubulin-targeting chemotherapy has been received growing attention in anticancer drug design and development. It was found that a number of naturally occurring compounds including distinct chalcones exert their effect by inhibition of tubulin polymerization. After the identification of tubulin polymerization as potential target for chalcone-type compounds, extensive researches have been made to design and synthesis of new anti-tubulin chalconoids. Although diverse chalcones have found to be potent anticancer agents but in the present review, we focused on the recently reported tubulin polymerization inhibitors from chalcone origin and related synthetic compounds, and their detailed synthetic methods and biological activities.

Keywords: 1,3-Diaryl-2-propen-1-ones; Anti-cancer; Chalcones; Cytotoxic activity; Tubulin polymerization.