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. 1989 Jun;82(3):203-7.
doi: 10.1007/BF00291154.

Preliminary exclusion of an X-linked gene in Leber optic atrophy by linkage analysis

J D Chen  1 , I Cox, M J Denton
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Preliminary exclusion of an X-linked gene in Leber optic atrophy by linkage analysis

J D Chen et al. Hum Genet. 1989 Jun.

Abstract

The maternal inheritance in Leber optic atrophy suggests that it may be caused by a cytoplasmic or mitochondrial defect. However, the strong male bias and the strict tissue specificity can not be readily explained by a single mitochondrial gene defect alone. Wallace suggested a hypothesis that the disease could be the result of an interaction between an X-linked gene and a mitochondrial DNA defect. Linkage relationships between Leber optic atrophy and 15 X-chromosome markers were analyzed in three large Tasmanian families. The results of two-point linkage analysis showed no close linkage between Leber optic atrophy and any of the 15 markers. The results of multipoint linkage analysis suggested the exclusion of the assumed X-linked gene from almost the whole X chromosome in these families.

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References

    1. Australas Ann Med. 1970 Aug;19(3):259-62 - PubMed
    1. Nature. 1981 Apr 9;290(5806):457-65 - PubMed
    1. Acta Ophthalmol (Copenh). 1985 Apr;63(2):135-45 - PubMed
    1. Birth Defects Orig Artic Ser. 1987;23(3):137-90 - PubMed
    1. J Med Genet. 1975 Mar;12(1):94-8 - PubMed

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