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. 2017 Feb;36(1):15-19.
doi: 10.1016/j.accpm.2016.01.007. Epub 2016 Jun 16.

What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey

F Aubrun  1 , E Chrétien  2 , L Letrilliart  3 , M Ginoux  4 , M Belhassen  4 , M Lanteri-Minet  5 , E Van Ganse  6 , H Beloeil  7 ; Sfar members of pain-ALR committee
Collaborators, Affiliations
Free article

What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey

F Aubrun et al. Anaesth Crit Care Pain Med. 2017 Feb.
Free article

Abstract

About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic had been prescribed, the prescriber's feedback following withdrawal, and the substitutive analgesics prescribed. DXP had been prescribed by more than 75% of the 430 anaesthesiologists and 230 pain specialists interviewed, mainly for acute and chronic non-cancer pain of moderate intensity. While two thirds of pain specialists were not satisfied with DXP withdrawal, this decision did not affect the majority of anaesthesiologists. In both groups, the main substitutive analgesic was tramadol combined with acetaminophen, while only 24% of prescribers considered acetaminophen alone as a substitute.

Keywords: Dextropropoxyphene; Pain; Treatment.

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Comment in

  • Are we missing dextropropoxyphene?
    Fletcher D. Fletcher D. Anaesth Crit Care Pain Med. 2017 Feb;36(1):3-4. doi: 10.1016/j.accpm.2016.12.001. Epub 2016 Dec 8. Anaesth Crit Care Pain Med. 2017. PMID: 27940014 No abstract available.