doi: 10.1073/pnas.75.2.559.
Respective roles of short- and long-range interactions in protein folding
- PMID: 273218
- PMCID: PMC411294
- DOI: 10.1073/pnas.75.2.559
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Respective roles of short- and long-range interactions in protein folding
Proc Natl Acad Sci U S A.
1978 Feb.
Abstract
A lattice model of protein is studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule is stabilized by specific long-range and short-ranged interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, it is concluded that the specific long-range interactions are essential for highly cooperative stabilization of the native conformation and that the short-range interactions accelerate the folding and unfolding transitions.
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