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Comment
. 2016 Sep;22(9):1689-91.
doi: 10.3201/eid2209.160692. Epub 2016 Sep 15.

Chromosomal Locations of mcr-1 and bla CTX-M-15 in Fluoroquinolone-Resistant Escherichia coli ST410

Linda Falgenhauer, Said-Elias Waezsada, Konrad Gwozdzinski, Hiren Ghosh, Swapnil Doijad, Boyke Bunk, Cathrin Spröer, Can Imirzalioglu, Harald Seifert, Alexandra Irrgang, Jennie Fischer, Beatriz Guerra, Annemarie Käsbohrer, Jörg Overmann, Alexander Goesmann, Trinad Chakraborty
Comment

Chromosomal Locations of mcr-1 and bla CTX-M-15 in Fluoroquinolone-Resistant Escherichia coli ST410

Linda Falgenhauer et al. Emerg Infect Dis. 2016 Sep.
No abstract available

Keywords: Colistin resistance gene mcr-1; ESBL; Escherichia coli; ST410; antimicrobial resistance; bacteria; extended-spectrum beta-lactamase; fluoroquinolones; sequence types.

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Figures

Figure
Figure
A) Genetic environment of mcr-1 in extended-spectrum β–lactamase (ESBL)–producing food isolates including the original environment found in pHNSHP45. Colors represent gene functions and insertion sequences: purple, transposase of ISApl1; dark blue, ISApl1 element; green, mcr-1; pink, hypothetical protein within the mcr-1 transposition unit; red, light blue, yellow, flanking genes specific for the respective isolate. B) Phylogenetic tree (unrooted) of the Escherichia coli sequence type 410 isolates harboring the blaCTX-M-15 transposition unit in the chromosome and a schematic depiction of the location of the mcr-1 and blaCTX-M-15 transposition unit. Isolates prefixed with the letter E represent consecutive isolates from 1 patient. Scale bar indicates nucleotide substitutions per site.
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References

    1. Liu Y-Y, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16:161–8. 10.1016/S1473-3099(15)00424-7 - DOI - PubMed
    1. Falgenhauer L, Waezsada S-E, Yao Y, Imirzalioglu C, Käsbohrer A, Roesler U, et al. RESET Consortium. Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing gram-negative bacteria in Germany. Lancet Infect Dis. 2016;16:282–3. 10.1016/S1473-3099(16)00009-8 - DOI - PubMed
    1. Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, Agersø Y, et al. Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill. 2015;20:30085. 10.2807/1560-7917.ES.2015.20.49.30085 - DOI - PubMed
    1. Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill. 2016;21:1–6. 10.2807/1560-7917.ES.2016.21.9.30155 - DOI - PubMed
    1. Vehreschild MJGT, Hamprecht A, Peterson L, Schubert S, Häntschel M, Peter S, et al. A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies. J Antimicrob Chemother. 2014;69:3387–92 . 10.1093/jac/dku305 - DOI - PubMed

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