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. 2016 Aug 22;60(9):5595-9.
doi: 10.1128/AAC.00389-16. Print 2016 Sep.

Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels

Jürgen Prattes  1 , Wiebke Duettmann  2 , Martin Hoenigl  3
Affiliations

Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels

Jürgen Prattes et al. Antimicrob Agents Chemother. .

Abstract

Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state.

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Figures

FIG 1
FIG 1
Box plots of PPCs obtained at pre-steady state and at early steady state in 48 patients with hematological malignancies.
FIG 2
FIG 2
Spaghetti blots of paired PPCs obtained at pre-steady state and at early steady state. Panel A displays pairs that had PPCs at both time points below or above the cutoff of 0.5 mg/liter, panel B displays pairs where PPCs decreased below the cutoff, and panel C displays pairs where PPCs increased above the cutoff. The cutoff of 0.5 mg/liter is displayed in all three panels as a dotted line.
FIG 3
FIG 3
(A) Scatter plot of correlation of PPCs obtained at pre-steady state with those obtained at early steady state. (B) ROC curve analysis of pre-steady-state PPCs for predicting PPCs above 0.5 mg/liter at early steady state.
See this image and copyright information in PMC

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