How to interpret mast cell tests
- PMID: 27325614
- DOI: 10.1136/archdischild-2015-309887
How to interpret mast cell tests
Abstract
Mast cell tryptase (tryptase) is an enzyme produced almost exclusively by mast cells that is easy to measure using a widely available test. In this article we discuss the physiology of the mast cell and how that relates to IgE-mediated anaphylaxis and mastocytosis. We also describe the technical aspects of testing tryptase and the reported normal ranges in health. Finally we explore the diagnostic performance of serum mast cell tryptase measurements, when used to confirm anaphylaxis, estimate future anaphylaxis risk and in diagnosing/monitoring leukaemia.
Keywords: Allergy; General Paediatrics; anaphylaxis; mastocytosis; tryptase.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Similar articles
-
Systemic mastocytosis presenting as intraoperative anaphylaxis with atypical features: a report of two cases.Anaesth Intensive Care. 2013 Jan;41(1):116-21. doi: 10.1177/0310057X1304100120. Anaesth Intensive Care. 2013. PMID: 23362901
-
The presence of mast cell clonality in patients with unexplained anaphylaxis.Clin Exp Allergy. 2014 Sep;44(9):1179-87. doi: 10.1111/cea.12369. Clin Exp Allergy. 2014. PMID: 25039926
-
Diagnostic value of tryptase in anaphylaxis and mastocytosis.Immunol Allergy Clin North Am. 2006 Aug;26(3):451-63. doi: 10.1016/j.iac.2006.05.010. Immunol Allergy Clin North Am. 2006. PMID: 16931288 Review.
-
Anaphylaxis with clonal mast cells in normal looking skin - a new entity?Allergy. 2015 Jul;70(7):864-72. doi: 10.1111/all.12634. Epub 2015 May 22. Allergy. 2015. PMID: 25899109
-
Management of Mediator Symptoms, Allergy, and Anaphylaxis in Mastocytosis.Immunol Allergy Clin North Am. 2023 Nov;43(4):681-698. doi: 10.1016/j.iac.2023.04.010. Epub 2023 Jun 4. Immunol Allergy Clin North Am. 2023. PMID: 37758406 Review.
Cited by
-
Causes and Diagnostic Usefulness of Tryptase Measurements for Anaphylaxis in a Korean Tertiary Care General Hospital.Yonsei Med J. 2022 Dec;63(12):1099-1105. doi: 10.3349/ymj.2022.0172. Yonsei Med J. 2022. PMID: 36444545 Free PMC article.
-
Tryptase in Acute Appendicitis: Unveiling Allergic Connections through Compelling Evidence.Int J Mol Sci. 2024 Jan 29;25(3):1645. doi: 10.3390/ijms25031645. Int J Mol Sci. 2024. PMID: 38338923 Free PMC article.
-
Anaphylaxis.Chest. 2018 Feb;153(2):528-543. doi: 10.1016/j.chest.2017.07.033. Epub 2017 Aug 8. Chest. 2018. PMID: 28800865 Free PMC article. Review.
-
Cutaneous Mastocytosis in Childhood-Update from the Literature.J Clin Med. 2021 Apr 2;10(7):1474. doi: 10.3390/jcm10071474. J Clin Med. 2021. PMID: 33918305 Free PMC article. Review.
-
Death Due to Anaphylactic Reaction: The Role of the Forensic Pathologist in an Accurate Postmortem Diagnosis.Medicina (Kaunas). 2023 Dec 15;59(12):2184. doi: 10.3390/medicina59122184. Medicina (Kaunas). 2023. PMID: 38138287 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
