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Comment
. 2016 Jun 20;26(12):R508-R511.
doi: 10.1016/j.cub.2016.05.021.

Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation

Roberta Caruso  1 , Gabriel Núñez  2
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Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation

Roberta Caruso et al. Curr Biol. .
Free article

Abstract

NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism.

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  • NOD1 and NOD2 signalling links ER stress with inflammation.
    Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. Keestra-Gounder AM, et al. Nature. 2016 Apr 21;532(7599):394-7. doi: 10.1038/nature17631. Epub 2016 Mar 23. Nature. 2016. PMID: 27007849 Free PMC article.

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