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Comment
. 2016 Jun 20;37(6):490-2.
doi: 10.1016/j.devcel.2016.06.003.

Nucleus to Mitochondria: Lost in Transcription, Found in Translation

Julie St-Pierre  1 , Ivan Topisirovic  2
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Nucleus to Mitochondria: Lost in Transcription, Found in Translation

Julie St-Pierre et al. Dev Cell. .
Free article

Abstract

Mitochondrial genes reside in the nucleus and mitochondria. In a recent paper in Nature, Couvillion et al. (2016) describe their development of a "mitoribosome profiling" approach and demonstrate that changes in expression of nuclear- and mitochondrial-encoded genes are coordinated at the level of translation during metabolic adaptation to fuel source changes.

Keywords: Mitochondrial biogenesis; Ribosome profiling; mRNA translation.

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