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Review
. 2016 Sep;28(5):544-9.
doi: 10.1097/BOR.0000000000000316.

Uveitis in children

Sheila T Angeles-Han  1 , Consuelo Egla Rabinovich
Affiliations
Review

Uveitis in children

Sheila T Angeles-Han et al. Curr Opin Rheumatol. 2016 Sep.

Abstract

Purpose of review: The review provides updates on novel risk markers for the development of pediatric inflammatory uveitis and a severe disease course, on treatment of refractory disease, and on the measurement of visual outcomes.

Recent findings: There are several new genetic markers, biomarkers, and clinical factors that may influence a child's uveitis disease course. It is important to identify children at risk for poor visual outcomes and who are refractory to traditional therapy. Racial disparities have recently been reported. We describe agents of potential benefit. In addition, we discuss the importance of patient reported outcomes in this population.

Summary: Uveitis can lead to vision-threatening complications. Timely and aggressive treatment of children identified to be at risk for a severe uveitis course may lead to improved outcomes.

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Conflict of interest statement

Conflicts of Interest: The Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q) has a license through Emory University but the authors have not received any royalties.

References

    1. Angeles-Han ST, McCracken C, Yeh S, et al. Characteristics of a cohort of children with Juvenile Idiopathic Arthritis and JIA-associated Uveitis. Pediatr Rheumatol Online J. 2015;13:19. * This study confirms known risk markers of uveitis, and reports on visual outcomes of a small group of African American children with JIA and uveitis.

    1. Gregory AC, 2nd, Kempen JH, Daniel E, et al. Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. Ophthalmology. 2013;120(1):186–192. - PMC - PubMed
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