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Review
. 2016 Oct;12(20):2379-86.
doi: 10.2217/fon-2016-0168. Epub 2016 Jun 22.

Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention

Jose Augusto Monteiro de Oliveira Novaes  1 , William N William Jr  1
Affiliations
Review

Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention

Jose Augusto Monteiro de Oliveira Novaes et al. Future Oncol. 2016 Oct.

Abstract

Oral squamous cell carcinomas represent a significant cancer burden worldwide. Unfortunately, chemoprevention strategies investigated to date have failed to produce an agent considered standard of care to prevent oral cancers. Nonetheless, recent advances in clinical trial design may streamline drug development in this setting. In this manuscript, we review some of these improvements, including risk prediction tools based on molecular markers that help select patients most suitable for chemoprevention. We also discuss the opportunities that novel preclinical models and modern molecular profiling techniques will bring to the prevention field in the near future, and propose a clinical trials framework that incorporates molecular prognostic factors, predictive markers and cancer biology as a roadmap to improve chemoprevention strategies for oral cancers.

Keywords: biomarkers; chemoprevention; head and neck cancer; leukoplakia; loss of heterozygosity; oral cancer; oral premalignant lesions; predictive markers; risk factor.

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Conflict of interest statement

Financial & competing interests disclosure This manuscript received funding from the following grants: P30 CA016672 from the National Cancer Institute – NIH; RP140464 from the Cancer Prevention and Research Institute of Texas. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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