Probable transfusion-transmitted Zika virus in Brazil
- PMID: 27329551
- DOI: 10.1111/trf.13681
Probable transfusion-transmitted Zika virus in Brazil
Abstract
Background: Zika virus (ZIKV) is an emerging arthropod-borne flavivirus transmitted by Aedes mosquitoes. Recent commentaries regarding ZIKV routes of transmission describe a potential transmission by transfusion. Herein, we report a probable case of transfusion-transmitted ZIKV infection through a platelet transfusion that was detected from postdonation information.
Case report: A blood donor made a voluntary telephone report to the blood donor facility 3 days after donation and informed the facility of a febrile illness (fever, malaise, and headaches). Due to the ongoing dengue epidemic, the initial clinical investigation included dengue among other possible diagnoses. The serology and molecular laboratory results excluded dengue infection. However, stored samples from the donation were positive for ZIKV on reverse transcription-polymerase chain reaction (RT-PCR) analysis. A retrospective investigation demonstrated that the platelet concentrate, which was part of a pool, had been transfused after a liver transplantation. A physician had evaluated the patient 4 days after surgery. Laboratory investigation showed enzyme-linked immunosorbent assay results that were negative for dengue immunoglobulin M antibodies; however, the results were positive for hemagglutination inhibition antibodies against flavivirus. ZIKV RT-PCR and virus isolation analyses in cell cultures from recipient serum were both positive. The sequencing confirmed ZIKV in the donor and patient samples. Ten partial nucleotide sequences from the ZIKV strain that were detected in the donor were aligned and compared with the ZIKV genome detected in the recipient, revealing a 99.8% homology between the two strains.
Conclusions: This is a case of probable transmission of ZIKV through blood transfusion. The patient had been transfused with the blood product from an infected donor, most likely in the incubation period after ZIKV infection but prior to clinical disease onset. This report emphasizes the importance of postdonation information and recipient investigations during outbreaks of potentially blood-borne infections.
© 2016 AABB.
Comment in
-
Assuring blood safety and availability: Zika virus, the latest emerging infectious disease battlefront.Transfusion. 2016 Jul;56(7):1669-72. doi: 10.1111/trf.13673. Transfusion. 2016. PMID: 27389990 No abstract available.
-
Documentation of transfusion-transmitted arbovirus infections in endemic areas.Transfusion. 2016 Dec;56(12):3143-3144. doi: 10.1111/trf.13861. Transfusion. 2016. PMID: 27933623 No abstract available.
Similar articles
-
How do we manage blood donors and recipients after a positive Zika screening result?Transfusion. 2017 Sep;57(9):2077-2083. doi: 10.1111/trf.14252. Epub 2017 Jul 21. Transfusion. 2017. PMID: 28734023
-
First cases of Zika virus-infected US blood donors outside states with areas of active transmission.Transfusion. 2017 Mar;57(3pt2):770-778. doi: 10.1111/trf.14041. Epub 2017 Feb 23. Transfusion. 2017. PMID: 28229475
-
Investigational Testing for Zika Virus among U.S. Blood Donors.N Engl J Med. 2018 May 10;378(19):1778-1788. doi: 10.1056/NEJMoa1714977. N Engl J Med. 2018. PMID: 29742375
-
Zika Virus and Patient Blood Management.Anesth Analg. 2017 Jan;124(1):282-289. doi: 10.1213/ANE.0000000000001770. Anesth Analg. 2017. PMID: 27902502 Review.
-
Zika Virus.Clin Microbiol Rev. 2016 Jul;29(3):487-524. doi: 10.1128/CMR.00072-15. Clin Microbiol Rev. 2016. PMID: 27029595 Free PMC article. Review.
Cited by
-
Zika Virus: Origins, Pathological Action, and Treatment Strategies.Front Microbiol. 2019 Jan 7;9:3252. doi: 10.3389/fmicb.2018.03252. eCollection 2018. Front Microbiol. 2019. PMID: 30666246 Free PMC article. Review.
-
Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract.Pathogens. 2018 May 11;7(2):51. doi: 10.3390/pathogens7020051. Pathogens. 2018. PMID: 29751638 Free PMC article. Review.
-
Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.PLoS One. 2017 Jan 31;12(1):e0171148. doi: 10.1371/journal.pone.0171148. eCollection 2017. PLoS One. 2017. PMID: 28141843 Free PMC article.
-
Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium.BMC Infect Dis. 2019 Dec 26;19(1):1081. doi: 10.1186/s12879-019-4685-9. BMC Infect Dis. 2019. PMID: 31878895 Free PMC article.
-
Production of Recombinant Zika Virus Envelope Protein by Airlift Bioreactor as a New Subunit Vaccine Platform.Int J Mol Sci. 2023 Sep 11;24(18):13955. doi: 10.3390/ijms241813955. Int J Mol Sci. 2023. PMID: 37762254 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical