Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review
- PMID: 27330369
- PMCID: PMC4908057
- DOI: 10.1016/j.jsps.2014.04.004
Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review
Abstract
For fearful and uncooperative children behavioral management techniques are used. In order to control the pain and anxiety in pedodontic patients, pharmacologic sedation, anesthesia and analgesia are commonly used. Midazolam is commonly used as an oral sedation agent in children; it has several features such as safety of use, quick onset and certain degree of amnesia that makes it a desirable sedation agent in children. This review paper discusses various aspects of oral midazolam, ketamine and their combinations in conscious sedation including, advantages of oral route of sedation, pharmacokinetics, range of oral doses, and antagonists for clinical dental treatment procedures.
Keywords: Ketamine; Oral midazolam; Pedodontics; Sedation in dentistry.
Similar articles
-
Intranasal sedation using ketamine and midazolam for pediatric dental treatment (NASO): study protocol for a randomized controlled trial.Trials. 2017 Apr 11;18(1):172. doi: 10.1186/s13063-017-1919-2. Trials. 2017. PMID: 28399933 Free PMC article. Clinical Trial.
-
Rectal Sedation With Ketamine and Midazolam in the Management of Uncooperative Children During Dental Treatment: A Case Series and Method Description.Cureus. 2024 Feb 24;16(2):e54825. doi: 10.7759/cureus.54825. eCollection 2024 Feb. Cureus. 2024. PMID: 38529445 Free PMC article.
-
Evaluation of Efficacy of Oral Ketamine and Midazolam Combination Drug in Different Doses in Different Groups Used for Moderate Sedation in Pediatric Dentistry Randomized-comparative Trial.Int J Clin Pediatr Dent. 2021;14(Suppl 2):S151-S156. doi: 10.5005/jp-journals-10005-2096. Int J Clin Pediatr Dent. 2021. PMID: 35645483 Free PMC article.
-
Considerations for submucosal midazolam administration in combination with oral and inhaled medications for sedation of pediatric dental patients.J Dent Anesth Pain Med. 2015 Jun;15(2):47-52. doi: 10.17245/jdapm.2015.15.2.47. Epub 2015 Jun 30. J Dent Anesth Pain Med. 2015. PMID: 28879258 Free PMC article. Review.
-
Best clinical practice guidance for conscious sedation of children undergoing dental treatment: an EAPD policy document.Eur Arch Paediatr Dent. 2021 Dec;22(6):989-1002. doi: 10.1007/s40368-021-00660-z. Epub 2021 Aug 28. Eur Arch Paediatr Dent. 2021. PMID: 34453697 Free PMC article. Review.
Cited by
-
Comparison of nitrous oxide/midazolam and nitrous oxide/promethazine for pediatric dental sedation: A randomized, cross-over, clinical trial.Dent Res J (Isfahan). 2018 Nov-Dec;15(6):411-419. Dent Res J (Isfahan). 2018. PMID: 30534169 Free PMC article.
-
Anesthetic approach to Niemann-Pick Type C patient for dental treatment.J Res Med Sci. 2017 Feb 16;22:25. doi: 10.4103/1735-1995.200276. eCollection 2017. J Res Med Sci. 2017. PMID: 28413422 Free PMC article. No abstract available.
-
Carers' and paediatric dentists' perceptions of children's pain during restorative treatment.Eur Arch Paediatr Dent. 2020 Apr;21(2):271-276. doi: 10.1007/s40368-019-00486-w. Epub 2019 Oct 17. Eur Arch Paediatr Dent. 2020. PMID: 31625120
-
Oral midazolam vs. intranasal dexmedetomidine plus oral midazolam for sedation of pediatric outpatients: a double-blinded randomized controlled trial.BMC Anesthesiol. 2023 Oct 10;23(1):341. doi: 10.1186/s12871-023-02289-5. BMC Anesthesiol. 2023. PMID: 37817075 Free PMC article. Clinical Trial.
-
Ultra-Low Frequency TENS as an Adjunctive Therapy for Pain Management in Non-Surgical Periodontal Treatment: A Pilot Study.Dent J (Basel). 2025 Apr 9;13(4):161. doi: 10.3390/dj13040161. Dent J (Basel). 2025. PMID: 40277491 Free PMC article.
References
-
- Adamowicz P., Kala M. Urinary excretion rates of ketamine and norketamine following therapeutic ketamine administration: method and detection window considerations. J. Anal. Toxicol. 2005;29:376–382. - PubMed
-
- Adams D., Dervay K.R. Pharmacology of procedural sedation. AACN Adv. Crit. Care. 2012;23:349–354. (quiz 355–6) - PubMed
-
- Agrawal D., Manzi S.F., Gupta R., Krauss B. Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. Ann. Emerg. Med. 2003;42:636–646. - PubMed
-
- Al-Zahrani A., Wyne A., Sheta S. Comparison of oral midazolam with a combination of oral midazolam and nitrous oxide–oxygen inhalation in the effectiveness of dental sedation for young children. J. Indian Soc. Pedod. Prev. Dent. 2009;27:9–16. - PubMed
-
- Beebe D.S., Belani K.G., Chang P., Hesse P.S., Schuh J.S., Liao J., Palahniuk R.J. Effectiveness of preoperative sedation with rectal midazolam, ketamine, or their combination in young children. Anesth. Analg. 1992;75:880–884. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical