Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May 14:5:621.
doi: 10.1186/s40064-016-2283-5. eCollection 2016.

Evaluation of survivin expression in prostate specimens of patients with prostate adenocarcinoma and benign prostate hyperplasia underwent transurethral resection of the prostate or prostatectomy

Mansooreh Eslami  1 , Tahere Khamechian  2 , Tahere Mazoochi  3 , Hasan Ehteram  1 , Mojtaba Sehat  1 , Javad Alizargar  4
Affiliations

Evaluation of survivin expression in prostate specimens of patients with prostate adenocarcinoma and benign prostate hyperplasia underwent transurethral resection of the prostate or prostatectomy

Mansooreh Eslami et al. Springerplus. .

Abstract

Background: Survivin is a newly found member of the inhibitors of apoptosis proteins, which plays a certain role in cancer. Survivin has a distinctly different expression in cancers, including prostate cancer. We are searching for the relationship between survivin levels in normal prostate tissue, benign prostate hyperplasia (BPH), and prostate adenocarcinoma in this study.

Results: The study surveyed 282 prostate samples, 94 normal, 94 BPH, and 94 prostate adenocarcinoma samples. Survivin expression was absent in normal prostate tissues. In the BPH group, the survivin expression level was higher than that of the normal group. In the adenocarcinoma group, the survivin expression level was higher than that of the BPH group. There was a significant association between survivin expression level and the adenocarcinoma stage.

Conclusion: Although there is no expression of survivin in normal prostate tissue, its expression is slightly positive in BPH. High survivin expression is related to a higher Gleason score in the adenocarcinoma of the prostate.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Different levels of survivin staining in the samples. a Negative, <10 % of epithelial cells weakly stained, b 1+, 10–29 % of epithelial cells stained weakly to moderate, c 2+, 30–49 % of epithelial cells stained moderately to intensive, d 3+, more than 50 % of epithelial cells stained intensely
Fig. 2
Fig. 2
Survivin expression percentage levels in different histopathological groups of prostate samples
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997;3:917. doi: 10.1038/nm0897-917. - DOI - PubMed
    1. Carswell BM, Woda BA, Wang X, Li C, Dresser K, Jiang Z. Detection of prostate cancer by alpha-methylacyl CoA racemase (P504S) in needle biopsy specimens previously reported as negative for malignancy. Histopathology. 2006;48(6):668–673. doi: 10.1111/j.1365-2559.2006.02409.x. - DOI - PubMed
    1. Cheung CH, Sun X, Kanwar JR, et al. A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF alpha therapy. Cancer Cell Int. 2010;10:36. doi: 10.1186/1475-2867-10-36. - DOI - PMC - PubMed
    1. Dabbs DJ. Diagnostic immunohistochemistry. 4. Amsterdam: Elsevier Health Sciences; 2013.
    1. de Almagro MC, Vucic D. The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy. Experimental oncology. 2012;34(3):200–211. - PubMed

LinkOut - more resources