Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov 27:7:8-11.
doi: 10.1016/j.mmcr.2014.11.003. eCollection 2015 Mar.

An unusual ulcer: A case of cutaneous mucormycosis caused by Rhizopus oryzae

Bradley J Gardiner  1 , Ian Simpson  2 , Mai H Khuu  3 , Sarah E Kidd  4 , Cheng H Lo  5 , Grant A Jenkin  6
Affiliations

An unusual ulcer: A case of cutaneous mucormycosis caused by Rhizopus oryzae

Bradley J Gardiner et al. Med Mycol Case Rep. .

Abstract

Mucormycoses are high-mortality infections feared by clinicians worldwide. They predominantly affect immunocompromised hosts and are associated with a spectrum of disease. We describe a case of cutaneous mucormycosis caused by Rhizopus oryzae in a patient with multiple risk factors cured with complete surgical excision and a short course of antifungal therapy.

Keywords: Amphotericin; Cutaneous mucormycosis; Posaconazole; Rhizopus oryzae.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Appearance of the ulcer on hospital admission (day 1).
Fig. 2
Fig. 2
Biopsy of ulcer performed on day 4: H&E stain, 400× (a) and PAS stain, 400× (b) showing narrow-angled branching fungal hyphae invading into necrotic dermis.
Fig. 3
Fig. 3
Sabouraud agar plate following 24 h incubation (a) and view from slide culture (40×) showing the presence and orientation of rhizoids (b).
Fig. 4
Fig. 4
Post-operative appearance (a) following initial surgery on day 21 and (b) following second wide local excision on day 24.
Fig. 5
Fig. 5
One month following grafting showing wound healing, complete graft take and no evidence of residual infection.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Roden M.M., Zaoutis T.E., Buchanan W.L. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41(5):634–653. - PubMed
    1. Spellberg B., Edwards J., Jr, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005;18(3):556–569. - PMC - PubMed
    1. Petrikkos G., Skiada A., Lortholary O. Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis. 2012;54(Suppl. 1):S23–S34. - PubMed
    1. Cornely O.A., Arikan-Akdagli S., Dannaoui E. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. Clin Microbiol Infect. 2014;20(Suppl. 3):S5–S26. - PubMed
    1. Clinical and Laboratory Standards Institute. Clinical and Laboratory Standards (CLSI) reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard (2nd ed., M38-A2). Wayne, PA, USA: CLSI; 2008.

LinkOut - more resources